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AZD7648 is a very potent and selective DNA-PK inhibitor. It is a sensitizer of radiation- and doxorubicin-induced DNA damage and sustained tumor regression in xenograft and patient-derived xenograft models. AZD7648 significantly enhances precise CRISPR/Cas9 gene editing alone or in combined treatment with a DNA polymerase theta inhibitor (2iHDR cocktail).
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