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BML-EI392

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Epoxide hydrolase inhibitor

Novel inhibitor of soluble epoxide hydrolase (IC₅₀=18nM and 69nM for the mouse and human enzymes respectively). Produces a hypotensive effect in angiotensin-infused rats and prevents and reverses cardiac hypertrophy in mouse models of cardiac hypertrophy.

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Product Details

Alternative Name	12-(3-Adamantan-1-yl-ureido)-dodecanoic acid
Appearance	White solid.
CAS	479413-70-2
Couple Target	Epoxide hydrolase
Couple Type	Inhibitor
Formula	C₂₁H₃₆N₂O₃
MW	392.5753
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (10mg/ml) or 100% ethanol (4mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store solutions at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Prevention and reversal of cardiac hypertrophy by soluble epoxide hydrolase inhibitors: D. Xu, et al.; PNAS U.S.A. 103, 18733 (2006), Abstract
An orally active epoxide hydrolase inhibitor lowers blood pressure and provides renal protection in salt-sensitive hypertension: J.D. Imig, et al.; Hypertension 46, 975 (2005), Abstract
Structural refinement of inhibitors of urea-based soluble epoxide hydrolases: C. Morisseau, et al.; Biochem. Pharmacol. 63, 1599 (2002), Abstract

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AUDA

BML-EI392

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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