AT-ODN-1 (endotoxin-free) (synthetic)

IFN-γ inducing non-CpG ODN of the AT-type, found in the Malaria genome; TLR9 (Toll-like receptor 9)-dependent immune activation.

CpG ODNs are well known for their immunostimulatory effect mediated by the activation of TLR9. It has been shown that not only CpG ODNs but also some AT-rich DNA fragments (AT-ODNs) are able to exert this effect. AT-ODNs with TLR9-activating and immunostimulatory properties were identified in Lactobacillus gasseri as well as in the malarial pathogen Plasmodium falciparum. AT-ODNs are useful tools for studying the role of TLR9 in the innate immunological response and in inflammation.