AS601245

ALX-270-443

Datasheet
Manual
SDS
CofA

Already have an account?

Jnk inhibitor

Potent and cell permeable ATP competitive JNK inhibitor (hJNK1: IC₅₀=150nM, hJNK2: IC₅₀=220nM and hJNK3: IC₅₀=70 nM). Displays anti-inflammatory properties and has been shown to reduce TNF-α plasma levels induced by LPS in mice.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	1,3-Benzothiazol-2-yl-(2-{[2-(3-pyridinyl)ethyl]amino}-4-pyrimidinyl) acetonitrile, JNK Inhibitor V
Appearance	White to yellow solid.
CAS	345987-15-7
Couple Target	Jnk
Couple Type	Inhibitor
Formula	C₂₀H₁₆N₆S
Identity	Determined by 1H-NMR.
MW	372.5
Purity	≥95% (HPLC)
Purity Detail	Sum of two isomers.
Solubility	Soluble in DMSO (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Hygroscopic. Packaged under inert gas. Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4: R. Kamata, et al.; PLoS One 11, e0165132 (2016), Application(s): Cell culture, Mouse aortic SMCs , Abstract — Full Text
Cortical interneurons require Jnk1 to enter and navigate the developing cerebral cortex: Myers, A. K., Meechan, D. W., et al.; J. Neurosci. 34, 7787 (2014), Abstract
TNFR1-JNK signaling is the shared pathway of neuroinflammation and neurovascular damage after LPS-sensitized hypoxic-ischemic injury in the immature brain: Wang, L. W., Chang, Y. C., et al.; J. Neuroinflammation 11, 215 (2014), Abstract
Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow: Ferreira, E., Porter, R. M., et al.; J. Biol. Chem. 288, 29494 (2013), Abstract
JNK signaling is the shared pathway linking neuroinflammation, blood-brain barrier disruption, and oligodendroglial apoptosis in the white matter injury of the immature brain: Wang, L. W., Tu, Y. F., et al.; J. Neuroinflammation 9, 175 (2012), Abstract
Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation: Tu, Y. F., Tsai, Y. S., et al.; J. Neuroinflammation 8, 40 (2011), Abstract
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase: P. Gaillard, et al.; J. Med. Chem. 48, 4596 (2005), Abstract
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties: S. Carboni, et al.; J. Pharmacol. Exp. Ther. 310, 25 (2004), Abstract — Full Text

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

AS601245

ALX-270-443

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project