AS-604850

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PI3 kinase p110γ inhibitor

Potent, cell permeable and ATP-competitive inhibitor of phosphoinositide 3-kinase γ (PI(3)Kγ). Exhibits selectivity over other PI(3)K isoforms.

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Alternative Name	5-(2,2-Difluoro-benzo[1,3]dioxol-5-ylmethylene)-thiazolidine-2,4-dione
Appearance	Off-white to yellow solid.
CAS	648449-76-7
Couple Target	PI3 kinase
Couple Type	Inhibitor
Formula	C₁₁H₅F₂NO₄S
MW	285.2
Purity	≥98% (HPLC (UV))
Solubility	Soluble in acetonitrile (6mg/ml), DMSO (50mg/ml), methanol (9mg/ml) or 100% ethanol.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

A novel TNFR1-triggered apoptosis pathway mediated by class IA PI3Ks in neutrophils: B. Geering, et al.; Blood 117, 5953 (2011), Abstract — Full Text
Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells: A. Bilancio, et al.; Blood 107, 642 (2006), Abstract — Full Text
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis: M. Camps, et al.; Nat. Med. 11, 936 (2005), Abstract

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