AS-252424

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PI3 kinase p110γ inhibitor

Potent and selective phosphoinositide 3-kinase (PI(3)K) p110γ inhibitor shown to be selective for class IB PI(3)K-mediated cellular effects.

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Alternative Name	5-[5-(4-Fluoro-2-hydroxyphenyl)-furan-2-ylmethylene)]-thiazolidine-2,4-dione
Appearance	Yellow-green to brownish solid.
CAS	900515-16-4
Couple Target	PI3 kinase
Couple Type	Inhibitor
Formula	C₁₄H₈FNO₄S
MW	305.3
Purity	≥98% (1H-NMR)
Solubility	Soluble in 100% ethanol (10mg/ml), DMSO (20mg/ml) or dimethyl formamide; also soluble in a 1:1 solution of DMSO:PBS, pH 7.4, (0.5mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 2 years after receip when stored at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Activation of phosphatidylinositol 3-kinase β by the platelet collagen receptors integrin α2β1 and GPVI: The role of Pyk2 and c-Cbl: D. Manganaro, et al.; Biochim. Biophys. Acta 1853, 1879 (2015), Application(s): Cell Culture, Abstract
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma: V. Pomel, et al.; J. Med. Chem. 49, 3857 (2006), Abstract — Full Text
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils: A.M. Condliffe, et al.; Blood 106, 1432 (2005), Abstract — Full Text

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