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Artemisinin

ALX-350-219

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iNOS inhibitor

Powerful antimalarial agent. Inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Crosses the blood-brain barrier. Inhibitor of human iNOS (NOS II).

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Product Details

Alternative Name	Qinghaosu
Appearance	White to off-white crystalline solid.
CAS	63968-64-9
Couple Target	NOS
Couple Type	Inhibitor
Formula	C₁₅H₂₂O₅
Identity	Determined by IR.
MI	14: 817
MW	282.4
Purity	≥98% (TLC)
RTECS	KD4170000
Solubility	Soluble in methanol, 100% ethanol, dimethyl formamide, DMSO or acetone; almost insoluble in water.
Source	Isolated from the traditional Chinese anti-malarial herb Artemisia annua L.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements: R.K. Haynes; Curr. Top. Med. Chem. 6, 509 (2006), Review, Abstract
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation: E. Aldieri, et al.; FEBS Lett. 552, 141 (2003), Abstract
The antimalaria agent artemisinin exerts antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies: M. Wartenberg, et al.; Lab. Invest. 83, 1647 (2003), Abstract
An over four millennium story behind qinghaosu (artemisinin)–a fantastic antimalarial drug from a traditional chinese herb: Y. Li & Y.L. Wu; Curr. Med. Chem. 10, 2197 (2003), Review, Abstract
Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication: M.A. van Agtmael, et al.; Trends Pharmacol. Sci. 20, 199 (1999), Review, Abstract
Inhibition of angiogenesis in embryoid bodies by artemisinin: M. Wartenberg, et al.; Pflugers Arch. Eur. J. Physiol. 445, S85 (1994)
The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives: X.D. Luo & C.C. Shen; Med. Res. Rev. 7, 29 (1987), Abstract
Qinghaosu (artemisinin): an antimalarial drug from China: D.L. Klayman; Science 228, 1049 (1985), Abstract

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Artemisinin

ALX-350-219

Product Details

Handling & Storage

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