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Aristolochic acid

ALX-270-047

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Reversible noncompetitive PLA₂ inhibitor.

Phospholipase A₂(PLA₂) inhibitor active against the enzymes found in many snake venoms as well as those of human platelets and synovial fluids. Inhibits ionophore-stimulated PLA₂activity in human neutrophils. Has been shown to be nephropathic and carcinogenic.

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Product Details

Alternative Name	8-Methoxy-6-nitrophenanthrol(3,4-d)-1,3-dioxide-5-carboxylic acid, 6-Nitrophenanthrol(3,4-d)-1,3-dioxide-5-carboxylic acid
Appearance	Yellow solid.
CAS	313-67-7 (Aristolochic acid I), 475-80-9 (Aristolochic acid II), 67123-64-2 (mixture)
Couple Target	PLA
Couple Type	Inhibitor
Formula	C₁₇H₁₁NO₇(Aristolochic acid I) and C₁₆H₉NO₆(Aristolochic acid II)
MI	14: 786
MW	341.3 (Aristolochic acid I) and 311.3 (Aristolochic acid II)
Purity	≥97% (~1:1 mixture of aristolochic acids I (A) and II (B))
RTECS	CF3325000
Solubility	Soluble in DMSO or 100% ethanol. Sparingly soluble in water.
Source	Isolated from Aristolochia.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process: J.J. Reina-Pinto, et al.; Plant Cell 21, 1252 (2009), Abstract — Full Text
Effect of aristolochic acid on intracellular calcium concentration and its links with apoptosis in renal tubular cells: Y.H. Hsin, et al.; Apoptosis 11, 2167 (2006), Abstract
Aristolochic acid and ’Chinese herbs nephropathy’: a review of the evidence to date: J.P. Cosyns; Drug Saf. 26, 33 (2003), Review, Abstract
Detection of DNA adducts formed by aristolochic acid in renal tissue from patients with Chinese herbs nephropathy: H.H. Schmeiser, et al.; Cancer Res. 56, 2025 (1996), Abstract
Selective inhibition of group II phospholipase A2 by quercetin: M. Lindahl & C. Tagesson; Inflammation 17, 573 (1993), Abstract
Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils: J.D. Winkler, et al.; Biochem. Pharmacol. 44, 2055 (1992), Abstract
The effects of the phospholipase A2 inhibitors aristolochic acid and PGBx on A23187-stimulated mobilization of arachidonate in human neutrophils are overcome by diacylglycerol or phorbol ester: M.D. Rosenthal, et al.; Biochim. Biophys. Acta 1126, 319 (1992), Abstract
Suramin alters phosphoinositide synthesis and inhibits growth factor receptor binding in HT-29 cells: R. Kopp & A. Pfeiffer; Cancer Res. 50, 6490 (1990), Abstract
Effects of aristolochic acid on phospholipase A2 activity and arachidonate metabolism of human neutrophils: M.D. Rosenthal, et al.; Biochim. Biophys. Acta 1001, 3 (1989), Abstract
Edema-inducing activity of phospholipase A2 purified from human synovial fluid and inhibition by aristolochic acid: B.S. Vishwanath, et al.; Inflammation 12, 549 (1988), Abstract

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Aristolochic acid

ALX-270-047

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