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Arginase I (human), (recombinant)

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Alternative Name	ARG1
Formulation	Liquid. In 10mM TRIS-HCl, pH 7.5, containing 1mM β-mercaptoethanol, 1mM MnCl₂ and 50% glycerol.
Purity	≥90% (SDS-PAGE)
Source	Produced in E. coli. Full length human arginase I.
Specific Activity	~2.0U/µg protein. One unit is defined as the amount of enzyme that converts 1µmol of L-arginine to L-ornithine and urea per min. at 37°C, pH 9.5 (R.T. Schminke, et al.; J. Biol. Chem. 238, 1012 (1962)).
UniProt ID	P05089

Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Inhibition of arginase by CB-1158 blocks myeloid cell-mediated immune suppression in the tumor microenvironment: S.M. Steggerda, et al.; J. Immunother. Cancer 5, 101 (2017), Abstract — Full Text
Increased levels of arginase in patients with acute hepatitis B suppress antiviral T cells: E. Sandalova, et al.; Gastroenterology 143, 78 (2012), Abstract
Biodegradable chitosan particles induce chemokine release and negligible arginase-1 activity compared to IL-4 in murine bone marrow-derived macrophages: J. Guzman-Morales, et al.; BBRC 405, 538 (2011), Abstract
Short-term correction of arginase deficiency in a neonatal murine model with a helper-dependent adenoviral vector: C.L. Gau, et al.; Mol. Ther. 17, 1155 (2009), Abstract
Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils: L.C. Jacobsen, et al.; Blood 109, 3084 (2007), Abstract
Implications of the S-shaped domain in the quaternary structure of human arginase: A. Mora, et al.; Biochim. Biophys. Acta 1476, 181 (2000), Abstract
Determination of arginase activity in macrophages: a micromethod: I.M. Corraliza, et al.; J. Immunol. Methods 174, 231 (1994), Abstract

Last modified: May 29, 2024

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