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Argatroban

BML-PI146

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Thrombin inhibitor

Argatroban is a synthetic peptidomimetic thrombin inhibitor which is in clinical use. It presents significant advantages as an anticoagulant in deep vein thrombosis, stroke prevention in atrial fibrillation and thromboembolic disease and especially in patients with coronary artery disease and heparin-induced thrombocytopenia.

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Product Details

Appearance	White to off-white powder.
CAS	74863-84-6
Couple Target	Thrombin
Couple Type	Inhibitor
Formula	C₂₃H₃₆N₆O₅S
Identity	Determined by NMR and LCMS.
MW	508.6
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection: J. Want, et al.; Neuropharmacology 105, 398 (2016), Application(s): Administered intravenously into rats, Abstract
Nafamostat mesilate improves function recovery after stroke by inhibiting neuroinflammation in rats: C. Li, et al.; Brain Behav. Immun. 56, 230 (2016), Application(s): Positive control, Abstract
Mannose-binding lectin promotes local microvascular thrombosis after transient brain ischemia in mice: X. de la Rosa, et al.; Stroke 45, 1453 (2014), Application(s): Used in osmotic pump with rat brain samples, Abstract
Thrombin activity associated with neuronal damage during acute focal ischemia: Chen, B., Friedman, B., et al.; J. Neurosci. 32, 7622 (2012), Abstract

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Argatroban

BML-PI146

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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