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Arcyriaflavin A

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CDK4/cyclin D1 inhibitor

Potent inhibitor of CDK4 / cyclin D1 (IC₅₀= 59nM). Inhibits human cytomegalovirus (HCMV) replication in cell culture (IC₅₀ = 200nM).

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Appearance	Orange to red solid.
CAS	118458-54-1
Couple Target	CDK, Cyclin
Couple Type	Inhibitor
Formula	C₂₀H₁₁N₃O₂
MW	325.3
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (50mg/ml).
Source	Synthetic. Originally isolated from the marine ascidian Eudistoma sp.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months at -20°C.
Handling	Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z(2)039-2: R. Liu, et al.; Arch. Pharm. Res. 30, 270 (2007), Abstract
Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors: C. Sanchez-Martinez, et al.; Bioorg. Med. Chem. Lett. 13, 3835 (2003), Abstract
Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors: G. Zhu, et al.; Bioorg. Med. Chem. Lett. 13, 1231 (2003), Abstract
Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication: M.J. Slater, et al.; Bioorg. Med. Chem. 7, 1067 (1999), Abstract
Staurosporine aglycone (K252-c) and arcyriaflavin A from the marine ascidian, Eudistoma sp: P.A. Horton, et al.; Experientia 50, 843 (1994), Abstract

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