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Arachidonyl-2-chloroethylamide

BML-FA032

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Cannabinoid receptor ligand

Non-pungent, potent and highly selective agonist of the cannabinoid CB₁ receptor (K_i=1.4nM). Displays >1’400-fold selectivity over CB₂ receptors (K_i=3.1µM). Active in vivo.

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Product Details

Alternative Name	ACEA, N-(2-Chloroethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Appearance	Pale yellow oil.
CAS	220556-69-4
Couple Target	Cannabinoid receptor
Couple Type	Ligand
Formula	C₂₂H₃₆NOCl
MW	366.0
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C when stored under an inert atmosphere.
Handling	Protect from air. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Modulation of trigeminal sensory neuron activity by the dual cannabinoid-vanilloid agonists anandamide, N-arachidonoyl-dopamine and arachidonyl-2-chloroethylamide: T.J. Price, et al.; Br. J. Pharmacol. 141, 1118 (2004), Abstract
The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints: C.L. Baker and J.J. McDougall; Br. J. Pharmacol. 142, 1361 (2004), Abstract — Full Text
Arachidonylcyclopropylamide increases microglial cell migration through cannabinoid CB2 and abnormal-cannabidiol-sensitive receptors: A. Franklin, et al.; Eur. J. Pharmacol. 474, 195 (2003), Abstract
Synthesis and characterization of potent and selective agonists of the neuronal cannabinoid receptor (CB1): C.J. Hillard, et al.; J. Pharmacol. Exp. Ther. 289, 1427 (1999), Abstract

Last modified: May 29, 2024

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Arachidonyl-2-chloroethylamide

BML-FA032

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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