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APLP2 is a member of an evolutionarily conserved APP family. APLP2 functions as a novel G(0)-protein-coupled receptor for Müllerian inhibiting substance (MIS) in cell survival. APLP2 is required for proper cell cycle exit of neuronal progenitors, and has a distinct role in priming cortical progenitors for neuronal differentiation. APLP2, a closely related homolog to AbetaPP, share overlapping anticoagulant functions with regard to regulating thrombosis after cerebral vascular injury.
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As a result of glycosylation, the recombinant protein migrates as an approximately 107.6 kDa protein in SDSPAGE under reducing conditions.
| Regulatory Status |
RUO – Research Use Only |
|---|
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| Purity | ≥90% (SDS-PAGE) |
|---|---|
| Source | Isolated from Crotalus durissus terrificus snake venom. |