Home Shop (+)-Aphidicolin

(+)-Aphidicolin

BML-CC101

Datasheet
Manual
SDS
CofA

Already have an account?

Reversible inhibitor of DNA polymerase a and d

Produced by Cephalosporium aphidicola and other fungi. A diterpene fungal metabolite that acts as reversible inhibitor of eukaryotic nuclear DNA replication. Useful for cell synchronization. Blocks the cell cycle at early S phase. Prolongs the half life of DNA methyltransferase. Specific inhibitor of DNA polymerase α and δ in eukaryotic cells and in some viruses of animal origin. Acts synergistically with vincristine and doxorubicin. Apoptosis inhibitor/inducer.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Appearance	White to off-white solid.
CAS	38966-21-1
Couple Target	DNA polymerase
Couple Type	Inhibitor
Formula	C₂₀H₃₄O₄
MI	14: 727
MW	338.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) or ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Replication stress drives chromosomal instability in fibroblasts of childhood cancer survivors with second primary neoplasms: S. Zahnreich, et al.; DNA Repair (Amst.) 122, 103435 (2023), Abstract
RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells: Santoriello, C., Sporrij, A., et al.; Nat. Cell Biol. 22, 372 (2020), Abstract
Compromised repair of radiation-induced DNA double-strand breaks in Fanconi anemia fibroblasts in G2: S. Zahnreich, et al.; DNA Repair. 96, 102992 (2020), Abstract
Developmental time rather than local environment regulates the schedule of epithelial polarization in the zebrafish neural rod: Girdler, G. C., Araya, C., et al.; Neural Dev. 8, 5 (2013), Abstract
Aphidicolin and bleomycin induced chromosome damage as biomarker of mutagen sensitivity: a twin study: B. Tedeschi, et al.; Mutat. Res. 546, 55 (2004), Abstract
Cytotoxicity of aphidicolin and its derivatives against neuroblastoma cells in vitro: synergism with doxorubicin and vincristine: M. Michaelis, et al.; Anticancer Drugs 11, 479 (2000), Abstract
Effect of aphidicolin on DNA methyltransferase in the nucleus: I. Suetake, et al.; Cell Struct. Funct. 23, 137 (1998), Abstract
Coordinate regulation of G- and C strand length during new telomere synthesis: X. Fan and C.M. Price; Mol. Biol. Cell 8, 2145 (1997), Abstract — Full Text
Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995), Abstract
TrkA neurogenic receptor regulates differentiation of neuroblastoma cells: W. Poluha, et al.; Oncogene 10, 185 (1995), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

(+)-Aphidicolin

BML-CC101

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project