Apamin

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K⁺ channel blocker

Originally isolated from Apis mellifera. A small conductance Ca²⁺-activated K⁺ channel blocker.

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Appearance	Lyophilized.
CAS	24345-16-2
Formula	C₇₉H₁₃₁N₃₁O₂₄S₄
MI	14: 725
MW	2027.3
Purity	≥95% (HPLC)
RTECS	CD6899900
Sequence	H-Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH₂ (Disulfide bonds between Cys¹-Cys¹¹and Cys³-Cys¹⁵)
Solubility	Soluble in 0.05M acetic acid (5mg/ml); slightly soluble in water (1mg/ml).
Source	Synthetic.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes.: A. Tse et al.; Science 255, 462 (1992), Abstract
Potassium channel toxins: P.N. Strong; Pharmacol. Ther. 46, 137 (1990), Abstract
Toxins in the characterization of potassium channels: N.A. Castle, et al.; TINS 12, 59 (1989), (Review), Abstract
Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle.: A.L. Blatz & K. L. Magleby; Nature 323, 718 (1986), Abstract
Apamin as a selective blocker of the calcium-dependent potassium channel in neuroblastoma cells: voltage-clamp and biochemical characterization of the toxin receptor.: M. Hugues et al.; PNAS 79, 1308 (1982), Abstract

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