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Apaf-1 monoclonal antibody (18H2)

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Alternative Name	Apoptosis protease-activating factor 1
Application	ELISA, ICC, IP, WB
Clone	18H2
Crossreactivity	Does not cross-react with rat Apaf-1.
Formulation	Liquid. Protein G purified antibody in PBS containing 0.02% sodium azide.
Host	Rat
Immunogen	Recombinant mouse Apaf-1 (apoptosis protease-activating factor-1) (aa 1-97) containing the N-terminal CARD domain.
Isotype	IgG2a
Species Reactivity	Human, Mouse
Specificity	Recognizes the CARD domain of Apaf-1.
UniProt ID	O88879
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Regulatory Status	RUO – Research Use Only

Apaf1 apoptotic function critically limits Sonic hedgehog signaling during craniofacial development: Long, A. B., Kaiser, W. J., et al.; Cell Death Differ. 20, 1510 (2013), Abstract
Apaf-1 and caspase-9 are required for cytokine withdrawal-induced apoptosis of mast cells but dispensable for their functional and clonogenic death: V.S. Marsden, et al.; Blood 107, 1872 (2006), Abstract — Full Text
Apaf-1 and caspase-9 do not act as tumor suppressors in myc-induced lymphomagenesis or mouse embryo fibroblast transformation: C.L. Scott, et al.; J. Cell Biol. 164, 89 (2004), Abstract — Full Text
Pro-apoptotic apoptosis protease-activating factor 1 (Apaf-1) has a cytoplasmic localization distinct from Bcl-2 or Bcl-x(L): G. Hausmann, et al.; J. Cell Biol. 149, 623 (2000), Abstract — Full Text

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