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Antimycin A

ALX-380-075

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Antibiotic

Antimycin A complex composed mostly of Antimycin A1, A2, A3, and A4
Used for the study of the mitochondrial function

Antimycin A is a bacterial metabolite complex produced by Streptomyces. It is composed majorly of Antimycin A1, A2, A3, and A4. Antimycin A is an antibiotic. It is capable of inducing apoptosis in mammalian cells, which is not prevented by the presence of Bcl-2. Antimycin A acts as an inhibitor of cellular respiration and more specifically, the electron transport chain of oxidative phosphorylation via its binding to cytochrome c reductase.

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Product Details

Alternative Name	Antipiricullin, Virosin
Appearance	White to faint yellow powder.
CAS	1397-94-0
Identity	Identity determined by NMR.
MI	14: 714 (A1) & 715 (A3)
RTECS	CD0350000
Solubility	Soluble in 100% ethanol (50mg/ml).
Source	Isolated from Streptomyces sp. Mixture of antimycin A’s.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration: Xiao, Y., Zhang, H., et al.; Nat. Commun. 16, 3012 (2025), Abstract
The absence of the ribosomal protein Rpl2702 elicits the MAPK-mTOR signaling to modulate mitochondrial morphology and functions: Liu, L., Wu, Y., et al.; Redox Biol. 73, 103174 (2024), Abstract
STAT3 modulates CD4+ T mitochondrial dynamics and function in aging: Zukowski, E., Sannella, M., et al.; Aging Cell 22, e13996 (2023), Abstract
Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease: Zeng, J., Acin-Perez, R., et al.; Nat. Commun. 14, 2573 (2023), Abstract
Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation: A.I. Hussein, et al.; Bone Rep. 18, 101657 (2023), Abstract
Near-anoxia induces immobilization and sustains viability of sperm stored in ant queens: A. Gotoh, et al.; Sci. Rep. 13, 3029 (2023), Abstract
The phloroglucinol calcitrinone A, a novel mitochondria-targeting agent, induces cell death in breast cancer cells: M.E. Gaafary, et al.; Food Chem. Toxicol. 162, 112896 (2022), Abstract
Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance: X. Li, et al.; Cell Rep. 36, 109607 (2021), Abstract
Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue: Ngo, J., Benador, I. Y., et al.; STAR Protoc. 2, 100243 (2021), Abstract
Unexpected Role of Sterol Synthesis in RNA Stability and Translation in Leishmania: Z. N. Karamysheva, et al.; Biomedicines 19, 696 (2021), Abstract

Last modified: May 29, 2024

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Antimycin A

ALX-380-075

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