Antibiotic
- Antimycin A complex composed mostly of Antimycin A1, A2, A3, and A4
- Used for the study of the mitochondrial function
Antimycin A is a bacterial metabolite complex produced by Streptomyces. It is composed majorly of Antimycin A1, A2, A3, and A4. Antimycin A is an antibiotic. It is capable of inducing apoptosis in mammalian cells, which is not prevented by the presence of Bcl-2. Antimycin A acts as an inhibitor of cellular respiration and more specifically, the electron transport chain of oxidative phosphorylation via its binding to cytochrome c reductase.
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Product Details
Alternative Name |
Antipiricullin, Virosin |
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Appearance |
White to faint yellow powder. |
CAS |
1397-94-0 |
Identity |
Identity determined by NMR. |
MI |
14: 714 (A1) & 715 (A3) |
RTECS |
CD0350000 |
Solubility |
Soluble in 100% ethanol (50mg/ml). |
Source |
Isolated from Streptomyces sp. Mixture of antimycin A’s. |
Handling & Storage
Use/Stability |
As indicated on product label or CoA when stored as recommended. |
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Handling |
Protect from light. |
Long Term Storage |
-20°C |
Shipping |
Ambient Temperature |
Regulatory Status |
RUO – Research Use Only |
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- Medium from human iPSC-derived primitive macrophages promotes adult cardiomyocyte proliferation and cardiac regeneration: Xiao, Y., Zhang, H., et al.; Nat. Commun. 16, 3012 (2025), Abstract
- The absence of the ribosomal protein Rpl2702 elicits the MAPK-mTOR signaling to modulate mitochondrial morphology and functions: Liu, L., Wu, Y., et al.; Redox Biol. 73, 103174 (2024), Abstract
- STAT3 modulates CD4+ T mitochondrial dynamics and function in aging: Zukowski, E., Sannella, M., et al.; Aging Cell 22, e13996 (2023), Abstract
- Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease: Zeng, J., Acin-Perez, R., et al.; Nat. Commun. 14, 2573 (2023), Abstract
- Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation: A.I. Hussein, et al.; Bone Rep. 18, 101657 (2023), Abstract
- Near-anoxia induces immobilization and sustains viability of sperm stored in ant queens: A. Gotoh, et al.; Sci. Rep. 13, 3029 (2023), Abstract
- The phloroglucinol calcitrinone A, a novel mitochondria-targeting agent, induces cell death in breast cancer cells: M.E. Gaafary, et al.; Food Chem. Toxicol. 162, 112896 (2022), Abstract
- Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance: X. Li, et al.; Cell Rep. 36, 109607 (2021), Abstract
- Isolation and functional analysis of peridroplet mitochondria from murine brown adipose tissue: Ngo, J., Benador, I. Y., et al.; STAR Protoc. 2, 100243 (2021), Abstract
- Unexpected Role of Sterol Synthesis in RNA Stability and Translation in Leishmania: Z. N. Karamysheva, et al.; Biomedicines 19, 696 (2021), Abstract
- COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10: M.C. Bradley, et al.; J. Biol. Chem. 295, 6023 (2020), Abstract — Full Text
- Dihydroartemisinin induces growth arrest and overcomes dexamethasone resistance in multiple myeloma: Y. Chen, et al.; Front. Oncol. 10, 767 (2020), Abstract — Full Text
- Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation: Bharath, L. P., Agrawal, M., et al.; Cell Metab. 32, 44 (2020), Abstract
- Measuring Mitochondrial Respiration in Previously Frozen Biological Samples: Osto, C., Benador, I. Y., et al.; Curr. Protoc. Cell Biol. 89, e116 (2020), Abstract
- Spatially stable mitochondrial compartments fuel local translation during plasticity: V. Rangaraju, et al.; Cell 176, 73 (2019), Abstract
- Mitochondrial dysfunction causes Ca2+ overload and ECM degradation–mediated muscle damage in C. elegans: S. Sudevan, et al.; FASEB J. 33, 9540 (2019), Abstract — Full Text
- Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux: D.P. Dannheisig, et al.; Cells 8, 894 (2019), Abstract — Full Text
- UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy: A.C. Bento, et al.; Sci. Rep. 8, 12415 (2018), Abstract — Full Text
- Measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in culture cells for assessment of the energy metabolism: B. Plizko, et al.; Bio. Protoc. 8, e2850 (2018), Abstract — Full Text
- The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells: B. Plitzko, et al.; J. Biol. Chem. 292, 21102 (2017), Abstract — Full Text
- The effect of phosphate availability on chondrocyte metabolic function: K. Blank, et al.; , (2016), (master’s thesis), Application(s): Inhibitor of complex III in the electron transport chain, Full Text
- PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia: Banh, R. S., Iorio, C., et al.; Nat. Cell Biol. 18, 803 (2016), Abstract
- An ROS generator, antimycin A, inhibits the growth of HeLa cells via apoptosis: W.H. Park, et al.; J. Cell. Biochem. 102, 98 (2007), Abstract
- Oligomycin and antimycin A prevent nitric oxide-induced apoptosis by blocking cytochrome C leakage: N. Dairaku, et al.; J. Lab. Clin. Med. 143, 143 (2004), Abstract
- Synthetic peptides and non-peptidic molecules as probes of structure and function of Bcl-2 family proteins and modulators of apoptosis: D. Liu & Z. Huang; Apoptosis 6, 453 (2001), Abstract
- Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3: S.P. Tzung, et al.; Nat. Cell. Biol. 3, 183 (2001), Abstract
- Biophysical characterization of recombinant human Bcl-2 and its interactions with an inhibitory ligand, antimycin A: K.M. Kim, et al.; Biochemistry 40, 4911 (2001), Abstract
- The effect of antimycin A on mouse liver inner mitochondrial membrane channel activity: M.L. Campo, et al.; J. Biol. Chem. 267, 8123 (1992), Abstract — Full Text
- The isolation and properties of antimycin A: B. R. Dunshee, et al.; J. Am. Chem. Soc. 71, 2436 (1949)
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