Home Shop Antibiotic A-23187 (Calcimycin)

Antibiotic A-23187 (Calcimycin)

BML-CA100

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Calcium ionophore

Antibiotic possessing weak in vitro antimicrobial activity against gram positive bacteria and fungi. A highly selective divalent cation ionophore, commonly used to increase intracellular Ca²⁺ levels in intact cells.

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Product Details

Appearance	Off-white solid.
CAS	52665-69-7
Formula	C₂₉H₃₇N₃O₆
MW	523.6
Purity	≥99% (TLC)
Solubility	Soluble in DMSO an, 100% ethanol or methylene chloride (10mg/ml); slightly soluble in water. Solubilize in DMSO or ethanol prior to preparing aqueous solutions of very low concentrations.
Source	Isolated from Streptomyces chartreusis

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. In aqueous systems product may aggregate over time. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese: Horning, K. J., Joshi, P., et al.; J. Biol. Chem. 295, 3875 (2020), Abstract
Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop: H. Shindou, et al.; FASEB J. 31, 2973 (2017), Abstract — Full Text
Disturbed B cell homeostasis in newly diagnosed giant cell arteritis and polymyalgia rheumatica: K.S. van der Geest, et al.; Arthritis Rheumatol. 66, 1927 (2014), Abstract
Enhanced assay of endothelial exocytosis using extracellular matrix components: M.B. LoMonaco, et al.; Anal. Biochem. 452, 19 (2014), Abstract — Full Text
Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species: T. Przygodzki et al.; Biochim. Biophys. Acta. 1740, 481 (2005), Abstract
Peripheral genotype-phenotype correlations in Asian Indians with type 2 diabetes mellitus: P.V. Rao et al.; J. Assoc. Physicians India 53, 521 (2005), Abstract
Molecular mechanisms of endothelium-mediated vasodilation: R.R. Fiscus et al.; Semin. Thromb. Hemost. 14 Suppl, 12 (1988), Abstract
A total synthesis of polyether antibiotic (-)-A23187 (calcimycin): D.P. Negri & Y. Kishi; Tetrahedron. Lett. 28, 1063 (1987)
Use of the ionophore A23187 to measure and control cytoplasmic Ca2+ levels in intact red cells: V.L. Lew & J. Garcia-Sancho; Cell. Calcium 6, 15 (1985), Abstract
Biological applications of ionophores: B.C. Pressman; Annu. Rev. Biochem. 45, 501 (1976), Abstract

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Antibiotic A-23187 (Calcimycin)

BML-CA100

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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