Home Shop Anti-Human Interferon Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)

Anti-Human Interferon Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)

PBL-21385

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Anti-IFNAR2 antibody (clone MMHAR-2) to human Interferon (Alpha, Beta and Omega) Receptor 2
IFN Receptor antibody blocks the biological action of Human Type I Interferons
Suitable for use in Type I IFN neutralization, flow cytometry, immunohistochemistry, and immunoprecipitation

Neutralizes human interferon alpha receptor; interacts with extracellular domain; binds to human interferon alpha receptor with high affinity; blocks biological action of Type I IFNs

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Neutralization Effect of PBL Anti-Human IFNAR2 Monoclonal Antibody (21385) on Human IFN-Alpha 2a and IFN-Beta Activities in an A549 Cell/EMCV CPE assay

Product Details

Alternative Name	IFN-α/β Receptor Chain 2, Interferon-α/β Receptor Chain 2
Clone	MMHAR-2
Formulation	Liquid. PBL-21385-1 (Unlabelled): In PBS containing 0.1% BSA. PBL-21385-3 (R-PE labelled): In PBS, pH 7.4, containing 1.5% BSA and 0.1% Kathon as preservative.
Host	Mouse
Immunogen	Human IFN alpha/beta RC2
Isotype	IgG2a
Species Reactivity	Human

Handling & Storage

Handling	For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep conjugated formats at +4°C. Do not freeze. Protect from light.
Long Term Storage	-20°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

CD4+T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors: X. Lei, et al.; Cell. Mol. Immunol. 21, 374 (2024), Abstract
Rickettsia rickettsii virulence determinants RARP2 and RapL mitigate IFN-b signaling in primary human dermal microvascular endotheial cells: L. Fitzsimmons, et al.; mBio 15, e0345023 (2024), Abstract
Autoimmunity in Down’s syndrome via cytokines, CD4 T cells and CD11c+ B cells: L. Malle, et al.; Nature 615, 305 (2023), Abstract
GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141: L. Naesens, et al.; Sci. Immunol. 7, eabq4531 (2022), Abstract
Antiviral Toll-Like Receptor Signal in Non-Parenchymal Liver Cells Is Restricted to TLR3: M. Werner, et al.; Viruses 14, 218 (2022), Abstract

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Anti-Human Interferon Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)

PBL-21385

Product Details

Handling & Storage

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