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Anisomycin

BML-ST102

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Activator of MAPK, Jnk and p38

Antibiotic. Activates JNK/SAPKs, p38 and MAP kinases but not ERKs leading to the phosphorylation of S6, histone H3 and HMG-14 and the induction of the immediate-early genes c-fos and c-jun. Induces apoptosis in the human monoblastoid cell line. Used at 300 ng/ml. Inhibits peptidyl transferase at higher concentrations. Used in the eradication of bean mildew. Inhibits other pathogenic fungi in plants.

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Product Details

Alternative Name	2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate
Appearance	White solid.
CAS	22862-76-6
Couple Target	Jnk, MAPK, p38
Couple Type	Activator
Formula	C₁₄H₁₉NO₄
MI	14: 670
MW	265.3
Purity	≥97% (TLC)
RTECS	BZ9800000
Solubility	Soluble in DMSO (25mg/ml).
Source	Isolated from Streptomyces griseolus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells: A.J. Browne, et al.; Cell Death Dis. 7, e2119 (2016), Application(s): Cell culture, Abstract
TR3 modulates platinum resistance in ovarian cancer: Wilson, A. J., Liu, A. Y., et al.; Cancer Res. 73, 4758 (2013), Abstract
Phosphorylation of serine 4,642 in the C-terminus of plectin by MNK2 and PKA modulates its interaction with intermediate filaments: Bouameur, J. E., Schneider, Y., et al.; J. Cell Sci. 126, 4195 (2013), Abstract
Anisomycin abrogates repression of protooncogene c-fos transcription in E1A + cHa-ras-transformed cells through activation of MEK/ERK kinase cascade: A. N. Kukushkin, et al.; J. Cell. Biochem. 103, 1005 (2008), Abstract
A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis: I.A. Mawji, et al.; Cancer Res. 67, 8307 (2007), Abstract
Anisomycin and the reconsolidation hypothesis: J.W. Rudy, et al.; Learn. Mem. 13, 1 (2006), Review, Abstract
Downregulation of Ski and SnoN co-repressors by anisomycin: A. Vazquez-Macias, et al.; FEBS Lett. 579, 3701 (2005), Abstract
Anisomycin treatment paradigm affects duration of long-term potentiation in slices of the amygdala: P. Okulski, et al.; Neuroscience 114, 1 (2002), Abstract
Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction: C.A. Hazzalin, et al.; Mol Cell Biol 18, 1844 (1998), Abstract
Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1: R. Zinck, et al.; Mol. Cell. Biol. 15, 4930 (1995), Abstract

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Anisomycin

BML-ST102

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