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Anacardic acid

ALX-270-381

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Cell permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase (HAT) activities (IC₅₀~8.5µM and ~5µM, respectively). Displays a variety of other biological activities, such as antibacterial, antimicrobial, prostaglandin synthase inhibition, tyrosinase, and lipoxygenase inhibition.Inhibits SUMOylation of RanGAP1-C2 with an IC₅₀ = 2.2µM

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Product Details

Alternative Name	2-Hydroxy-6-pentadecylbenzoic acid, 6-Pentadecylsalicylic acid, AA
Appearance	White to off-white solid.
CAS	16611-84-0
Couple Target	HAT, Lipoxygenase, Tyrosinase
Couple Type	Inhibitor
Formula	C₂₂H₃₆O₃
MI	14: 621
MW	348.5
Purity	≥95% (HPLC)
Solubility	Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Discovery and Characterization of BAY-184: A New Potent and Selective Acylsulfonamide-Benzofuran In Vivo-Active KAT6AB Inhibitor: A.T. Laak, et al.; J. Med. Chem. 67, 19282 (2024), Abstract
Molecular and functional characterization of an evolutionarily conserved CREB-binding protein in the Lymnaea CNS: D. Hatakeyama, et al.; FASEB J. 36, e22593 (2022), Abstract
Rab17 Regulates apical delivery of hepatic transcytotic vesicles: A.C. Striz, et al.; Mol. Biol. Cell. 29, 2887 (2018), Abstract — Full Text
The inhibitory effects of anacardic acid on hepatitis C virus life cycle: J. Hundt, et al.; PLoS One 10, e0117514 (2015), Application(s): Assay, Cell Culture, Abstract — Full Text
Effects of natural nuclear factor-kappa B inhibitors on anticancer drug efflux transporter human P-glycoprotein: T. Nabekura, et al.; Biomed. Pharmacother. 70, 140 (2015), Application(s): Cell Culture, Abstract
Ehrlichia chaffeensis exploits host SUMOylation pathways to mediate effector-host interactions and promote intracellular survival: Dunphy, P. S., Luo, T., et al.; Infect. Immun. 82, 4154 (2014), Abstract
CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells: Trisciuoglio, D., Ragazzoni, Y., et al.; Clin. Cancer Res. 18, 475 (2012), Abstract
Analysis of protein dynamics at active, stalled, and collapsed replication forks: Sirbu, B. M., Couch, F. B., et al.; Genes Dev. 25, 1320 (2011), Abstract
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate: I. Fukuda, et al.; Chem. & Biol. 16, 133 (2009), Abstract
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation: Y. Sun, et al.; FEBS Lett. 580, 4353 (2006), Abstract

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Anacardic acid

ALX-270-381

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Handling & Storage

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