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Anabasine . hydrochloride

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Acetylcholine receptor activator

Tobacco alkaloid. Potent nicotinic acetylcholine receptor agonist. Insecticide.

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Alternative Name	3-(2-Piperidinyl)pyridine, 2-(3-Pyridyl)piperidine, Neonicotine
Appearance	White to off-white solid.
CAS	15251-47-5
Couple Target	Acetylcholine receptor
Couple Type	Activator
Formula	C₁₀H₁₄N₂ . HCl
MI	14: 619
MW	162.2 . 36.5
Purity	≥97% (TLC, NMR)
Solubility	Soluble in alcohol or water.
Source	Isolated from Anabasis aphylla.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Anabasine toxicity from a topical folk remedy: N.G. Murphy, et al.; Clin. Pediatr. (Phila) 45, 669 (2006), Abstract
Simultaneous and sensitive measurement of anabasine, nicotine, and nicotine metabolites in human urine by liquid chromatography-tandem mass spectrometry: X. Xu, et al.; Clin. Chem. 50, 2323 (2004), Abstract
Anabasine, a selective nicotinic acetylcholine receptor agonist, antagonizes MK-801-elicited mouse popping behavior, an animal model of schizophrenia: J. Mastropaolo, et al.; Behav. Brain Res. 153, 419 (2004), Abstract
Anabasine and anatabine as biomarkers for tobacco use during nicotine replacement therapy: P. Jacob, 3rd, et al.; Cancer Epidemiol. Biomarkers Prev. 11, 1668 (2002), Abstract
Nicotine, cotinine, and anabasine inhibit aromatase in human trophoblast in vitro: R.L. Barbieri, et al.; J. Clin. Invest. 77, 1727 (1986), Abstract

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