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Ampicillin . sodium salt

ALX-380-268

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Antibiotic

β-Lactam antibiotic. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking). Inactivates transpeptidases on the inner surface of the bacterial cell membrane. Effective against Gram-negative and Gram-positive bacteria. Is inactivated by β-lactamase.

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Product Details

Alternative Name	D-(-)-α-Aminobenzylpenicillin . Na
Appearance	White to light yellow powder.
CAS	69-52-3
Couple Target	Transpeptidase
Couple Type	Inhibitor
Formula	C₁₆H₁₈N₃O₄S . Na
MI	14: 586
MW	348.4 . 23.0
Purity	Assay (anhydrous basis): 845-988 µg/mg.
RTECS	XH8400000
Solubility	Soluble in water (50mg/ml).
Source	Semisynthetic from penicillin.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Nucleic acid hybridization-based detection of pathogenic RNA using microscale thermophoresis: M.Y. Avivi, et al.; J. Biol. Chem. 300, 105676 (2024), Abstract
Nerve growth factor and epidermal growth factor rescue PC12 cells from programmed cell death induced by etoposide: distinct modes of protection against cell death by growth factors and a protein-synthesis inhibitor: M. Nakajima, et al.; Neurosci. Lett. 176, 161 (1994), Abstract
Schedule-dependent effects of two consecutive, divided, low doses of actinomycin D on translocation of protein B23, inhibition of cell growth and RNA synthesis in HeLa cells: B.Y. Yung, et al.; Int. J. Cancer 52, 317 (1992), Abstract
Induction of apoptosis (programmed cell death) in human leukemic HL-60 cells by inhibition of RNA or protein synthesis: S.J. Martin, et al.; J. Immunol. 145, 1859 (1990), Abstract
Short exposure to actinomycin D induces reversible” translocation of protein B23 as well as “”reversible”” inhibition of cell growth and RNA synthesis in HeLa cells”””: B.Y. Yung, et al.; Cancer Res. 50, 5987 (1990), Abstract
Sulbactam/ampicillin. A review of its antibacterial activity, pharmacokinetic properties, and therapeutic use: D.M. Campoli-Richards & R.N. Brogden; Drugs 33, 577 (1987), Abstract
N7-Substituted 7-aminoactinomycin D analogues. Synthesis and biological properties: M.S. Madhavarao, et al.; J. Med. Chem. 21, 958 (1978), Abstract
7-substituted actinomycin D analogs. Chemical and growth-inhibitory studies: S.K. Sengupta, et al.; J. Med. Chem. 18, 1175 (1975), Abstract

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Last modified: May 29, 2024

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Ampicillin . sodium salt

ALX-380-268

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