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Aminopurvalanol A

ALX-270-249

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CDK/cyclin inhibitor

Cell permeable, reversible and competitive inhibitor of CDK1/cyclin B (IC₅₀=33nM), CDK2/cyclin A (IC₅₀=33nM), CDK2/cyclin E (IC₅₀=28nM) and CDK5/p35 (IC₅₀=20nM).

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Product Details

Alternative Name	(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
Appearance	White to brownish solid.
CAS	220792-57-4
Couple Target	CDK, Cyclin
Couple Type	Inhibitor
Formula	C₁₉H₂₆N₇OCl
Identity	Determined by NMR.
MW	403.9
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO or methanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Packaged under inert gas.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

M-phase regulation of the recruitment of mRNAs onto polysomes using the CDK1/cyclin B inhibitor aminopurvalanol: M. Le Breton, et al.; BBRC 306, 880 (2003), Abstract
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors: Y.T. Chang, et al.; Chem. Biol. 6, 361 (1999), Abstract
A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts: G.R. Rosania, et al.; PNAS 96, 4797 (1999), Abstract — Full Text

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Aminopurvalanol A

ALX-270-249

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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