AMG-9810

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TRPV1 antagonist

AMG-9810 is an antagonist of capsaicin activation of TRPV1 (IC₅₀=24.5 nM) as well as activation by acid, heat, and endogenous ligands.

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Appearance	Off-white solid.
CAS	545395-94-6
Couple Target	TRP channel
Couple Type	Blocker
Formula	C₂₁H₂₃NO₃
MW	337.4
Purity	≥98%
Solubility	Soluble in DMSO (>25mg/ml); ethanol (20mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties: N. R. Gavva, et al.; J. Pharmacol. Exp. Ther. 313, 474 (2005), Abstract — Full Text

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