AM-580

BML-GR104

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Retinoic acid receptor ligand

Retinoic acid analog which acts as a selective RARα agonist with no affinity for RXRs. Induces differentiation in leukemia cell lines and inhibits angiogenesis in chick embryos.

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Product Details

Appearance	White to off-white solid.
CAS	102121-60-8
Couple Target	Retinoic acid receptor
Couple Type	Ligand
Formula	C₂₂H₂₅NO₃
MW	351.4
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (25mg/ml) and ethanol (10mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells: M. Gianni, et al.; Blood 87, 1520 (1996), Abstract
Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs: S.C. Brooks, et al.; Blood 87, 227 (1996), Abstract
Three novel synthetic retinoids, Re 80, Am 580 and Am 80, all exhibit anti-angiogenic activity in vivo: T. Oikawa, et al.; Eur. J. Pharmacol. 249, 113 (1993), Abstract
Selective synthetic ligands for human nuclear retinoic acid receptors: B. Martin, et al.; Skin Pharmacol. 5, 57 (1992), Abstract

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AM-580

BML-GR104

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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