Aloesin

ALX-350-158

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Tyrosinase inhibitor

C-glycosylated chromone compound. Competitive inhibitor of tyrosinase. Shows weak free radical scavenging activity. Anti-inflammatory. Modulates melanogenesis (pigmentation-altering agent). Used in the cosmetic industry.

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Product Details

Alternative Name	Aloeresin B, NSC 631262, 8-β-D-Glucopyranosyl-7-hydroxy-5-methyl-2-(2-oxopropyl)-4H-1-benzopyran-4-one
Appearance	Pale yellow to brown powder.
CAS	30861-27-9
Couple Target	Tyrosinase
Couple Type	Inhibitor
Formula	C₁₉H₂₂O₉
Identity	Identity determined by 1H-NMR and MS.
MW	394.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO or 100% ethanol.
Source	Isolated from Aloe sp.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Determination of aloesin and aloeresin A for the detection of aloe in beverages: M. Dell Agli, et al.; J. Agric. Food Chem. 55, 3363 (2007), Abstract
Aloeresin I, an anti-inflammatory 5-methylchromone from cape aloe: G. Speranza, et al.; Planta Med. 71, 79 (2005), Abstract
Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera: A. Yagi, et al.; Planta Med. 68, 957 (2002), Abstract
Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase: K. Jones, et al.; Pigment Cell Res. 15, 335 (2002), Abstract
Mushroom tyrosinase inhibition activity of some chromones: L.Z. Piao, et al.; Chem. Pharm. Bull. (Tokyo) 50, 309 (2002), Abstract
Aloesin inhibits hyperpigmentation induced by UV radiation: S. Choi, et al.; Clin. Exp. Dermatol. 27, 513 (2002), Abstract
Aloesin up-regulates cyclin E/CDK2 kinase activity via inducing the protein levels of cyclin E, CDK2, and CDC25A in SK-HEP-1 cells: K.Y. Lee, et al.; Biochem. Mol. Biol. Int. 41, 285 (1997), Abstract
Chromones in aloe species. I. Aloesin–a C-glucosyl-7-hydroxychromone: D.K. Holdsworth; Planta Med. 19, 322 (1971), Abstract
The distribution of aloesin in some South African Aloe species: T.J. McCarthy & L.J. Haynes; Planta Med. 15, 342 (1967), Abstract

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Aloesin

ALX-350-158

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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