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ALK5 Inhibitor II

ALX-270-445

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TGF-β type I receptor kinase (ALK5) inhibitor

Potent ATP-competitive inhibitor of the TGF-β type I receptor ALK5
Useful for cellular reprogramming and the culture of human pluripotent stem cells
Active in vitro and in vivo
GMP format available

ALK5 inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC₅₀=23nM, 4nM and 18nM for binding, auto-phosphorylation, and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). It minimally affects a panel of nine closely related kinases including p38 MAPKand GSK3 (IC₅₀>16µM). It can be used for the induction of the pluripotency of stem cells by replacing the transcription factor SOX2 via the inhibition of TGF-β signaling and inducing the expression of the transcription factor Nanog.

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Product Details

Alternative Name	TGF-β RI Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, RepSox, E-616452, SJN 2511
Appearance	White to off-white or yellow solid.
CAS	446859-33-2
Couple Target	TGF-beta receptor
Couple Type	Inhibitor
Formula	C₁₇H₁₃N₅
Identity	Identity determined by NMR.
MW	287.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (5 mg/ml) or methanol (5 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Controlling Human Stem Cell-Derived Islet Composition Using Magnetic Sorting: Kelley, A. B., Shunkarova, M., et al.; Biotechnol. Bioeng. 122, 2206 (2025), Abstract
Depolymerizing F-actin accelerates the exit from pluripotency to enhance stem cell-derived islet differentiation: Hogrebe, N. J., Schmidt, M. D., et al.; bioRxiv , (2024)
Cell identity dynamics and insight into insulin secretagogues when employing stem cell-derived islets for disease modeling: Wang, C., Abadpour, S., et al.; Front. Bioeng. Biotechnol. 12, 1392575 (2024), Abstract
Controlling human stem cell-derived islet composition using magnetic sorting: Kelley, A. B., Shunkarova, M., et al.; bioRxiv , (2024)
Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells: Lim, S. W., Shin, Y. J., et al.; Kidney Res. Clin. Pract. 43, 236 (2024), Abstract
Pump-Less, Recirculating Organ-on-Chip (rOoC) Platform to Model the Metabolic Crosstalk between Islets and Liver: Aizenshtadt, A., Wang, C., et al.; Adv. Healthc. Mater. 13, e2303785 (2024), Abstract
NEUROD2 function is dispensable for human pancreatic β cell specification: Cota, P., Saber, L., et al.; Front. Endocrinol. (Lausanne) 14, 1286590 (2023), Abstract
Regulation of CTCF loop formation during pancreatic cell differentiation: Lyu, X., Rowley, M. J., et al.; Nat. Commun. 14, 6314 (2023), Abstract
Insulin regulates human pancreatic endocrine cell differentiation in vitro: P. Cota, et al.; Mol. Metab. 79, 101853 (2023), Abstract
Prediction of diabetes mellitus development after kidney transplantation using patient-specific induced pluripotent stem cells: Lim, S. W., Shin, Y. J., et al.; Research Square , (2022)

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ALK5 Inhibitor II

ALX-270-445

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