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Antibiotic that increases membrane permeability
Mixture of alamethicin homologs. Membrane permeabilizing antibiotic. Applications include increasing [32P] incorporation into phosphatidylinositol 4-phosphate and permeabilization of sarcoplasmic reticulum vesicles. Causes fusion of lipid vesicles.
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Product Details
| Alternative Name |
U-22324 |
|---|---|
| Appearance |
White to off-white solid. |
| CAS |
27061-78-5 |
| Formula |
C92H150N22O25 |
| MW |
1964.3 |
| Purity |
≥98% (TLC) |
| Sequence |
Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Gln-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Gln-L-phenylalaninol |
| Solubility |
Soluble in DMSO, 100% ethanol or methanol. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C. |
|---|---|
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Selective metabolic regulations by p53 mutant variants in pancreatic cancer: Caporali, S., Butera, A., et al.; J. Exp. Clin. Cancer Res. 43, 310 (2024), Abstract
- HRK downregulation and augmented BCL-xL binding to BAK confer apoptotic protection to therapy-induced senescent melanoma cells: Alcon, C., Kovatcheva, M., et al.; Cell Death Differ. , (2024), Reactant(s): Human, Abstract
- TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions: M. Münchhalfen, et al.; Nat. Commun. 15, 6971 (2024), Abstract
- Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML: Popescu, B., Stahlhut, C., et al.; Cell Rep. Med. 4, 101290 (2023), Abstract
- Genetic and compound screens uncover factors modulating cancer cell response to indisulam: Z. Pogacar, et al.; Life Sci. Alliance 5, e202101348 (2022), Reactant(s): Human, Abstract — Full Text
- MEK and MCL-1 sequential inhibition synergize to enhance rhabdomyosarcoma treatment: C. Alcon, et al.; Cell Death Discov. 8, 172 (2022), Abstract
- An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities: R. Flümann, et al.; Blood Cancer Discov. 2, 70 (2021), Abstract — Full Text
- Therapeutic Synergy in Esophageal Cancer and Mesothelioma Is Predicted by Dynamic BH3 Profiling: D.R. Surman, et al.; Mol. Cancer Ther. 20, 1469 (2021), Reactant(s): Human, Abstract — Full Text
- Nicotinamide riboside supplementation confers marginal metabolic benefits in obese mice without remodeling the muscle acetyl-proteome: A.S. Williams, et al.; iScience 25, 103635 (2021), Abstract — Full Text
- MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia: A. Manzano-Muñoz, et al.; Front. Cell Dev. Biol. 9, 695225 (2021), Abstract — Full Text
- Dynamic BH3 profiling method for rapid identification of active therapy in BH3 mimetics resistant xenograft mouse models: E.A. Olesinski, et al.; STAR Protoc. 2, 100461 (2021), Abstract — Full Text
- The effect of mitochondrial calcium uniporter and cyclophilin D knockout on resistance of brain mitochondria to Ca2+-induced damage: J. Hamilton, et al.; J. Biol. Chem. 296, 100669 (2021), Abstract — Full Text
- ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins: C. Alcon, et al.; Cells 10, 1659 (2021), Reactant(s): Human, Abstract
- Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction: A.S. Williams, et al.; Cell Metab. 31, 131 (2020), Abstract — Full Text
- Sequential combinations of chemotherapeutic agents with BH3 mimetics to treat rhabdomyosarcoma and avoid resistance: C. Alcon, et al.; Cell Death Dis. 11, 634 (2020), Abstract — Full Text
- Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia: S. Bhatt, et al.; Cancer Cell 38, 872 (2020), Reactant(s): Human, Abstract — Full Text
- Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling: F. Seyfried, et al.; Cell Death Dis. 10, 571 (2019), Abstract — Full Text
- Inhibitor Combined with Venetoclax Rescues Venetoclax-Resistant Acute Myelogenous Leukemia: H.E. Ramsey, et al.; Cancer Discov. 8, 1566 (2018), Abstract — Full Text
- Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells: B.D. Landry, et al.; Mol. Syst. Biol. 14, e8322 (2018), Abstract — Full Text
- Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation: J. Dai & M.A. Luftig; J. Immunol. 200, 1727 (2018), Abstract — Full Text
- Measurements of Alamethicin and Gramicidin Reconstituted in Biomimetic Block Copolymers: M. Martin, et al.; Langmuir 33, 1171 (2017), Abstract
- Intracellular BH3 profiling reveals shifts in anti-apoptotic dependency in B-cell maturation and activation: Dai, J., Luftig, M. A., et al.; bioRxiv , (2017), Reactant(s): Human
- Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current: S. Futaki & K. Asami; Chem. Biodivers. 4, 1313 (2007), Review, Abstract
- Channel-forming activity of alamethicin: effects of covalent tethering: G.A. Woolley; Chem. Biodivers. 4, 1323 (2007), Review, Abstract
- Model ion channels: gramicidin and alamethicin: G. A. Woolley & B. A. Wallace; J. Membr. Biol. 129, 109 (1992), Review, Abstract
- Regulation of polyphosphoinositide synthesis in cardiac membranes: E. Quist, et al.; Arch. Biochem. Biophys. 271, 21 (1989), Abstract
- The production of alamethicins by Trichoderma spp: D. Brewer, et al.; Can. J. Microbiol. 33, 619 (1987), Abstract
- Adenylate cyclase in sarcoplasmic reticulum of skeletal muscle: distribution, orientation, and regulation: M. Nakagawa & J.H. Willner; J. Cyclic Nucleotide Protein Phosphor. Res. 11, 237 (1986), Abstract
- The use of ionophores and channel formers in the study of the function of biological membranes: A. Gomez-Puyou & C. Gomez-Lojero; Curr. Top. Bioener. 6, 221 (1977)
- Alamethicin-mediated fusion of lecithin vesicles: A.L.Y. Lau and S.I. Chan; PNAS 72, 2170 (1975), Abstract
- The primary structure of alamethicin: J.W. Payne, et al.; Biochem. J. 117, 757 (1970), Abstract
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