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Akt inhibitor VIII

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Potent inhibitor of Akt1, Akt2 and Akt3 activity.

A cell-permeable compound that potently, selectively and reversibly inhibits Akt1/Akt2/Akt3 activity.

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Alternative Name	Akti-1/2, Isozyme-selective Akt inhibitor VIII, 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one, Imidazoquinoxaline 16h
Appearance	Off-white to yellow powder.
CAS	612847-09-3
Couple Target	Akt
Couple Type	Inhibitor
Formula	C₃₄H₂₉N₇O
MW	551.6
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Short Term Storage	-20°C
Long Term Storage	-80°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Comparative Analysis of CTRP-Mediated Effects on Cardiomyocyte Glucose Metabolism: Cross Talk between AMPK and Akt Signaling Pathway: L. Li, et al.; Cells 10, 905 (2021), Abstract
Carboxyl group-modified α-lactalbumin induces TNF-α-mediated apoptosis in leukemia and breast cancer cells through the NOX4/p38 MAPK/PP2A axis: J.T. Chiou, et al.; Int. J. Biol. Macromol. 187, 513 (2021), Abstract
Phospholipase D2 restores endothelial barrier function by promoting PTPN14-mediated VE-cadherin dephosphorylation: Fu, P., Ramchandran, R., et al.; J. Biol. Chem. 295, 7669 (2020), Abstract
Role of Sphingosine Kinase 1 and S1P Transporter Spns2 in HGF-mediated Lamellipodia Formation in Lung Endothelium: Fu, P., Ebenezer, D. L., et al.; J. Biol. Chem. 291, 27187 (2016), Abstract

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