AIP (myristoylated)

Autocamtide-2-related inhibitory peptide (myristoylated)

Powder.

Lyophilized. Trifluoroacetate salt.

Determined by MS.

1708.1

≥95% (HPLC)

N-Myr-Lys-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu

Soluble in 30% Acetic Acid in Water (5 mg/ml).

Synthetic.

AIP (autocamtide-2-related inhibitory peptide, Prod. No. BML-P211) is a highly-specific and potent inhibitor of CaM kinase II. The sequence is derived from autocamtide-2 (Prod. No. BML-P101) but alanine is substituted for threonine at the 9-position.  AIP at 1 µM completely inhibited CaM kinase II but did not affect PKC, PKA, CaMKIV and other brain extract kinases. Myristoylated AIP (Prod. No. BML-P212) is the same sequence as AIP but is N-terminal myristoylated to increase cell-permeability.