AICAR

BML-EI330

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AMPK activator

An adenosine analog that is phosphorylated in whole cells to form 5-aminoimidazole-4-carboxamide-1-D-ribofuranosyl-5’-monophosphate (ZMP), which stimulates AMPK activity. AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown. Induces the phosphorylation of TORC2 and inhibits its entry into the nucleus. Mimics the effects of insulin on the expression of two gluconeogenic genes PEPCK and glucose-6-phosphatase. Inhibits PPARα coactivation and adipocyte differentiation. Substrate for the AICAR transformylase activity of ATIC. Inhibits the growth of prostate cancer cells by inhibiting fatty ascid synthesis. Supresses LPS-induced TNF production via the inhibition of Akt activation. Induces apoptosis in Jurkat cells via a non-AMPK pathway.

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Product Details

Alternative Name	5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside, Acadesine
Appearance	Off-white solid.
CAS	2627-69-2
Couple Target	AICAR transformylase, AMPK
Couple Type	Activator, Substrate
Formula	C₉H₁₄N₄O₅
MW	258.2
Purity	≥98% (TLC)
Solubility	Soluble in water (9mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

PTEN inhibits AMPK to control collective migration: Peglion, F., Capuana, L., et al.; Nat. Commun. 13, 4528 (2022), Abstract
Inhibitory role of AMP‑activated protein kinase in necroptosis of HCT116 colon cancer cells with p53 null mutation under nutrient starvation: D.T. Le, et al.; Int. J. Oncol. 54, 702 (2019), Abstract
Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms: M. Panse, et al.; PLoS One 13, e0198016 (2018), Abstract — Full Text
Resveratrol Up-regulates AMPA Receptor Expression via AMP-activated protein kinase – mediated Protein Translation: G. Wang, et al.; Neuropharmacology 95, 144 (2015), Application(s): Cell Culture, Western Blotting, Abstract
Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 MAPK signalling and Mac-1 activation: Rossi, A., Lord, J., et al.; PLoS One 8, e69108 (2013), Abstract
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism: S. H. Koo et al.; Nature 437, 1109 (2005), Abstract
Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase: M. Bronner et al.; Biochem. J. 384, 295 (2004), Abstract
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms: X. Xiang et al.; Biochem. Biophys. Res. Commun. 321, 161 (2004), Abstract
5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages: B. S. Jhun et al.; Biochem. Biophys. Res. Commun. 318, 372 (2004), Abstract
5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved: J. M. Lopez et al.; Biochem. J. 370, 1027 (2003), Abstract

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AICAR

BML-EI330

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