AG-126

BML-EI263

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Inhibits tyrosine kinase-dependent B cell receptor signaling

AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42^MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

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Product Details

Alternative Name	3-Hydroxy-4-nitrobenzylidenemalononitrile
Appearance	Yellow solid.
CAS	118409-62-4
Formula	C₁₀H₅N₃O₃
MW	215.2
MeltingPoint	181-182°C
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Store tightly sealed in the dark. Protect from light.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Stage-Specific Expression of TNFα Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells: W. Wang, et al.; PLoS One 6, e16740 (2011), Abstract — Full Text
The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat: L. Dugo, et al.; Intensive Care Med. 28, 775 (2002), Abstract
The Tyrosine Kinase Inhibitor Tyrphostin AG126 Reduces the Development of Acute and Chronic Inflammation: S. Cuzzocrea, et al.; Am. J. Pathol. 157, 145 (2000), Abstract — Full Text
The Tyrosine Kinase Inhibitor Tyrphostin AG 126 Reduces the Development of Colitis in the Rat: S. Cuzzocrea, et al.; Lab. Invest. 80, 1439 (2000), Abstract — Full Text
Tyrosine kinase inhibition: an approach to drug development: A. Levitzki & A. Gazit; Science 267, 1782 (1995), Abstract
Protein-tyrosine kinase activity tightly associated with human type II Fc gamma receptors: G. Sarmay, et al.; PNAS 91, 4140 (1994), Abstract
Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors: A. Novogrodsky, et al.; Science 264, 1319 (1994), Abstract
Receptor-mediated activation of human B lymphocytes in a nonphosphotyrosine-dependent manner: C.M. Roifman & G. Wang; J. Immunol. 149, 1179 (1992), Abstract
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract

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AG-126

BML-EI263

Product Details

Handling & Storage

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