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AE 51310 is a potent antagonist of the GPCR OPN4/melanopsin. OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. AE 51310 decreased the growth and proliferation of both LG17 and LG55 lung cancer tumors in mouse xenograft models.
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Last modified: February 27, 2025