ADP-HPD

ADP-HPD is a highly potent, noncompetitive and specific inhibitor of poly-(ADP-ribose) glycohydrolase (PARG; IC50 = 120 nM), displaying a 1000-fold lower IC50 compared to native hydrolase product ADPR (IC50 = 120 µM). The NAD glycohydrolase from Bungarus fusciutus venom is less sensitive to inhibition by ADP-HPD, exhibiting an IC50 = 260 µM. ADP-HPD does not inhibit either poly(ADP-ribose) polymerase (PARP) or NAD:arginine mono(ADP-ribosyl)-transferase A at inhibitor concentrations up to 1 mM. ADP-HPD has been widely used in PAR research, besides numerous other applications, for example in crystallization experiments with PARG, to investigate the structure and function of PARG, and to measure PARP activity in permeabilized cells.

BLG-A471-025 (5 x 0.5 µmol pack size) is not sold in the U.S. or Canada. Please contact us for available options.