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Adiponectin (mouse), (recombinant)

ALX-522-059

12 citations

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Homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity

Mimics serum adiponectin by forming high molecular weight (HMW) and hexameric species
Expressed in mammalian cell line to guarantee proper post-translational modifications
High purity and low endotoxin content to ensure experimental success

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so serum glucose levels decrease until counter-regulatory mechanisms (i.e. glucagon) become effective. rhACRP30headless demonstrated no significant bioactivity in terms of reduction of serum glucose compared to wildtype in this in vivo assay.""""" — **Figure 1:** Bioactivity of rmsAdiponectin.Method: 2 groups of 4 mice each were injected with PBS (vehicle), rmAdiponectin (Prod. No. ALX-522-059) and rhACRP30headless (tail adiponectin) (Prod. No. ALX-203-002) at 1µg/g body weight as a tail vein injection. Subsequently

Adiponectin (mouse), (recombinant) image — **Figure 2:** Superdex 200 analysis of Adiponectin (mouse) (recombinant) (Prod. No. ALX-522-059) produced in mammalian cells (HEK 293). The different forms of adiponectin are indicated by arrows: High molecular weight (HMW; representing 12-18-mer species) and hexamer. The red arrow indicates where should elute the trimeric state of adiponectin. *For further information on adiponectin forms, see Tsao et al., 2002 and Pajvani et al., 2003, in General Literature References.*“””,Adiponectin (mouse)

Product Details

Alternative Name	Adipocyte complement related protein of 30kDa, ACRP30, AdipoQ, apM1, GBP28
Concentration	0.5mg/ml after reconstitution.
Formulation	Lyophilized. Contains PBS.
MW	~35kDa (SDS-PAGE).
Purity	≥90% (SDS-PAGE)
Reconstitution	Reconstitute with 100µl sterile water.
Source	Produced in HEK 293 cells. Mouse adiponectin (aa 18-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG^®-tag.
Technical Info / Product Notes	Historical data has shown that adiponection inhibits serum glucose production in mice and protects mouse hepatocytes from TNF-α-induced cell death in vitro. FLAG is a registered trademark of Sigma-Aldrich Co.
UniProt ID	Q60994

Handling & Storage

Use/Stability	Stable for at least 6 months after receipt when stored at -20°C.
Handling	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Adiponectin ameliorates placental injury in gestational diabetes mice by correcting fatty acid oxidation/peroxide imbalance-induced ferroptosis via restoration of CPT-1 activity: Y. Zheng, et al.; Endocrine 75, 781 (2022), Application(s): In vivo use, Abstract
Adiponectin regulates electroacupuncture-produced analgesic effects in association with a crosstalk between the peripheral circulation and the spinal cord: Z. Ning, et al.; Brain Behav. Immun. 99, 43 (2022), Application(s): In vivo use, Abstract
Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring: O.R. Vaughan, et al.; Int. J. Obes. 44, 488 (2020), Application(s): In vivo use, Abstract — Full Text
Heat shock protein 60 (HSP60) modulates adiponectin signaling by stabilizing adiponectin receptor: D. Zhang, et al.; Cell Commun. Signal. 18, 60 (2020), Application(s): In vitro use with cells, Abstract — Full Text
AdipoRon attenuates Wnt signaling by reducing cholesterol-dependent plasma membrane rigidity: M.L. Salinas, et al.; Biophys. J. 118, 885 (2020), Application(s): In vitro use with cells, Abstract — Full Text
Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring: M.E. Paulsen, et al.; FASEB J. 33, 2899 (2019), Abstract
Adiponectin links maternal metabolism to uterine contractility: Vyas, V., Guerra, D. D., et al.; FASEB J. 33, 14588 (2019), Abstract
Adiponectin and adiponectin receptor 1 overexpression enhance inflammatory bowel disease: Y.J. Peng, et al.; J. Biomed. Sci. 25, 24 (2018), Abstract — Full Text
Photoreceptor glucose metabolism determines normal retinal vascular growth: Z. Fu, et al.; EMBO Mol. Med. 10, 76 (2018), Abstract — Full Text
Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth: I.L. Aye, et al.; PNAS 112, 12858 (2015), Abstract — Full Text

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Adiponectin (mouse), (recombinant)

ALX-522-059

Product Details

Handling & Storage

Resources

Metabolism

Cellular Therapy

Cardiovascular Research

Drug Discovery

AMPIVIEW® RNA Probes

Immuno-Oncology

AMPIGENE® PCR Solutions

Bioprocess

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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