Adapalene

BML-GR111

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Retinoic acid receptor ligand

Adapalene is a stable analog of retinoic acid and acts selectively as an agonist at RARβ and RARγ. It inhibits proliferation and induces apoptosis in colorectal cancer cells. Its unique pharmacological properties make it superior to other retinoids for the treatment of acne.

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Product Details

Alternative Name	6-[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid
Appearance	White solid.
CAS	106685-40-9
Couple Target	Retinoic acid receptor
Couple Type	Ligand
Formula	C₁₉H₃₄O₃
MW	412.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (3 mg/mL) or DMF (6 mg/mL).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store, as supplied, at room temperature for up to 1 year. Store solutions at-20°C for up to 3 months.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro: M. Ocker, et al.; Int. J. Cancer 107, 453 (2003), Abstract
Adapalene: an update on newer comparative studies between the various retinoids: L. E. Milikan, et al.; Int. J. Dermatoil. 39, 784 (2000), Abstract
Pharmacology of adapalene: S. Michel, et al.; Br. J. Dermatol. 139, 52 (1998), Abstract

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Adapalene

BML-GR111

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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