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ADAM17 (CT) polyclonal antibody

ADI-905-249

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TNF-alpha converting enzyme (TACE) is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), and is responsible for the cleavage of membrane-bound precursor TNF-alpha to its mature, secreted form. TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP).

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This antibody is covered by our Worry-Free Guarantee.

ADAM17 (CT) polyclonal antibody Western blot — Western blot analysis of TACE in HeLa and Jurkat whole cell lysate in the absence or presence of blocking peptide with TACE antibody at 1:500 dilution.

ADAM17 (CT) polyclonal antibody Immunocytochemistry — Immunocytochemistry analysis of TACE in HeLa cells with TACE antibody at 10µg/ml.

Product Details

Alternative Name	TACE, A disintegrin and metalloproteinase 17
Application	ICC, WB
Application Notes	Detects bands of ~80 to ~130kDa (may represent mature protein, precursor, and glycosylated TACE) by Western blot.
Formulation	Liquid. In PBS containing 0.02% sodium azide.
Host	Rabbit
Immunogen	Synthetic peptide corresponding to the sequence near the C-terminus of human ADAM17.
Purity Detail	Peptide affinity purified.
Recommendation Dilutions/Conditions	Western Blot (1:500-1:2,000)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application.
Species Reactivity	Human, Mouse, Rat
UniProt ID	P78536
Worry-free Guarantee	This antibody is covered by our Worry-Free Guarantee.

Handling & Storage

Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin: S.O. Mattila, et al.; FASEB J. 35, e21654 (2021), Abstract
Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer’s disease: B. Ray, et al.; Transl. Psychiatry 10, 81 (2020), Abstract — Full Text
High Glucose Upregulates ADAM17 through HIF-1α in Mesangial Cells: R. Li, et al.; J. Biol. Chem. 290, 21603 (2015), Application(s): Immunofluorescence, Abstract — Full Text
Functional and molecular evidence for expression of the renin angiotensin system and ADAM17-mediated ACE2 shedding in COS7 cells.: Grobe, N., Di Fulvio, M., et al.; Am. J. Physiol. Cell Physiol. 308, C767 (2015), Application(s): ICC-IF / Reactant(s): Green monkey, Abstract
Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice: Salem, E. S., Grobe, N., et al.; Am. J. Physiol. Renal Physiol. 306, F629 (2014), Abstract