Actinonin

ALX-260-128

Datasheet
Manual
SDS
CofA

Already have an account?

Protease inhibitor

Antibiotic. Inhibitor of aminopeptidase M, N and leucine and alanyl aminopeptidase and peptide deformylase (PDF). Inhibits MMP-1 (K_i=300nM), MMP-2 (IC₅₀~90nM at MMP-2=5nM), MMP-3 (K_i=1’700nM), MMP-7 (IC₅₀~3’500nM at MMP-7=19nM), MMP-8 (K_i=160nM), MMP-9 (K_i=330nM), MMP-10 (IC₅₀~500nM at MMP-10=22nM), MMP-12 (IC₅₀~350nM at MMP-12=4nM), and MMP-13 (IC₅₀~100nM at MMP-13=13nM), but not MMP-14 (IC₅₀>1mM at MMP-14=13.6nM). Shows antitumor activity in vitro and in vivo. Apoptosis inducer.

Shipping: Available products typically ship within 24/48h, via priority shipping.

Do you need support? Contact Customer Service or Technical Support.

Online Account
Access or Create Your Account

Product Details

Alternative Name	3[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]-carbonyl]-2-methylpropyl]-carbamoyl]-octanohydroxamic acid
Appearance	White to off-white powder.
CAS	13434-13-4
Couple Target	Aminopeptidase, MMP, MMP-1, MMP-10, MMP-12, MMP-13, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, Peptide deformylase
Couple Type	Inhibitor
Formula	C₁₉H₃₅N₃O₅
MW	385.5
Purity	≥98% (HPLC)
Solubility	Soluble in 100% ethanol (20mg/ml) or DMSO (>20mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation: E.L. Orth-He, et al.; Cell Rep. 42, 111965 (2023), Abstract
Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasis: H.Y. Imoto, et al.; Cell Rep. 38, 110444 (2022), Abstract
System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity: Yang, C. I., Zhu, Z., et al.; iScience 25, 104756 (2022), Abstract
Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination: Y. Oshima, et al.; J. Cell Biol. 220, 202006043 (2021), Abstract
Formyl-methionine as a degradation signal at the N-termini of bacterial proteins: K.I. Piatkov, et al.; Microb. Cell 2, 376 (2015), Application(s): Cell Culture, Abstract — Full Text
Actinonin induces apoptosis in U937 leukemia cells: M. Grujic, et al.; Cancer Lett. 223, 211 (2005), Abstract
Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics: M.D. Lee, et al.; J. Clin. Invest. 114, 1107 (2004), Abstract
Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor: D.Z. Chen, et al.; Biochemistry 39, 1256 (2000), Abstract
Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299: U. Lendeckel, et al.; BBRC 252, 5 (1998), Abstract
Antitumor activity of actinonin in vitro and in vivo: Y. Xu, et al.; Clin. Cancer Res. 4, 171 (1998), Abstract

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Datasheet

Certificate of Analysis

Please enter the lot number as featured on the product label

Lot No. :

SDS

Enzo Life Science provides GHS Compliant SDS

English (EU) SDS

If your language is not available please fill out the SDS request form

Your Cart

Your Cart

Actinonin

ALX-260-128

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

Change Country

Tell us about You

Tell us about your paper

Tell us about You

Tell us about your project