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Actinomycin D

BML-GR300

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Intercalating transcription inhibitor

An intercalating transcription inhibitor and antineoplastic antibiotic. Inhibits transcription by binding to DNA at dG residues. Induces apoptosis in many cell lines, but suppresses in PC12 cells induced by topoisomrease II inhibitor etopside. Used at 5-10µg/ml in cell culture for haltiong transcription. The product is not sterile.

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Product Details

Appearance	Red-orange crystalline solid.
CAS	50-76-0
Formula	C₆₂H₈₆N₁₂O₁₆
MW	1255.5
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>20mg/ml), 100% ethanol (1mg/ml) or methanol.
Source	Isolated from Streptomyces parvulus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Sensitive to strong acids and bases. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Handling	Protect from light. Hygroscopic.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Human Smc5/6 recognises transcription-generated positive DNA supercoils: Diman, A., Panis, G., et al.; Nat. Commun. 15, 7805 (2024), Abstract
Role of Human Antigen R (HuR) in the Regulation of Pulmonary ACE2 Expression: N. Alofi, et al.; Cells 11, 3390 (2022), Abstract
SMNDC1 links chromatin remodeling and splicing to regulate pancreatic hormone expression: T. Casteels, et al.; Cell Rep. 40, 111288 (2022), Abstract
PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug: T. He, et al.; J. Exp. Clin. Cancer Res. 34, 152 (2015), Application(s): Cell culture, Abstract — Full Text
The Wnt target protein Peter Pan defines a novel p53-independent nucleolar stress response pathway: A.S. Pfister, et al.; J. Biol. Chem. 290, 10905 (2015), Application(s): Cell Culture, Abstract — Full Text
The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells: Liu, Y., Gilbert, M. R., et al.; Acta Neuropathol. 128, 723 (2014), Abstract
miR-524-5p suppresses the growth of oncogenic BRAF melanoma by targeting BRAF and ERK2: Liu, S. M., Lu, J., et al.; Oncotarget 5, 9444 (2014), Abstract
Induction of carbonyl reductase 1 (CBR1) expression in human lung tissues and lung cancer cells by the cigarette smoke constituent benzo[a]pyrene: Kalabus, J. L., Cheng, Q., et al.; Toxicol. Lett. 211, 266 (2012), Abstract
Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress: Nostramo, R., Tillinger, A., et al.; J. Endocrinol. 215, 291 (2012), Abstract
Actinomycin D enhances TRAIL-induced caspase-dependent and -independent apoptosis in SH-SY5Y neuroblastoma cells: M. J. Wang et al.; Neurosci. Res. 59, 40 (2007), Abstract

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Actinomycin D

BML-GR300

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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