ACP

ALX-430-118

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Probe for oxidative stress detection

Cell permeable probe for the detection of intracellular oxidative stress. ACP can easily be deprotected with esterases to cyclic hydroxylamines, which are oxidized by ROS leading to ESR-detectable nitroxide radicals.

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Product Details

Alternative Name	1-Acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine
Appearance	White to off-white crystalline powder.
Formula	C₁₁H₂₀N₂O₃
MW	228.3
Purity	≤0.05% paramagnetic impurities (by EPR)
Solubility	Soluble in water, methanol, 100% ethanol or DMSO.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Pharmacokinetic study of acyl-protected hydroxylamine probe, 1-acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine, for in vivo measurements of reactive oxygen species: K. Saito, et al.; Free Radic. Biol. Med. 36, 517 (2004), Abstract
Measurement of oxidative stress by EPR radical-probe technique: L. Valgimigli, et al.; Free Radical Biol. Med. 31, 708 (2001), (Review), Abstract
Sensitive ESR determination of intracellular oxidative stress by using acyl-protected hydroxylamines as new spin reagents: O. Itoh, et al.; Chem. Lett. 29, 304 (2000), Abstract
In vivo EPR imaging by using an acyl-protected hydroxylamine to analyze intracerebral oxidative stress in rats after epileptic seizures: H. Yokoyama, et al.; Magn. Reson. Imaging 18, 875 (2000), Abstract

Last modified: May 29, 2024

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ACP

ALX-430-118

Product Details

Handling & Storage

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