Acivicin

BML-EI113

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Irreversible inhibitor of γ-glutamyl transpeptidase (GGT) ID₅₀ = 0.54 mM. Inhibits the enzymatic conversion of leukotriene C₄ to leukotriene D₄. Displays antitumor and anti-metastatic activity. Blocks H. Pylori GGT-induced T-cell inhibition. Inhibits bioactivation/release of nitric oxide from GSNO.

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Product Details

Alternative Name	U-42126, AT-125
Appearance	White solid.
CAS	42228-92-2
Couple Target	gamma-Glutamyl transpeptidase
Couple Type	Inhibitor
Formula	C₅H₇ClN₂O₃
MW	178.6
Purity	≥98% (HPLC)
Solubility	Soluble in water (max. 18mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione: P.C. Turnbull, et al.; Am. J. Physiol. Cell Physiol. 317, C1278 (2019), Abstract — Full Text
Functional characterisation of glutathione export from the rat lens: A. Umapathy, et al.; Exp. Eye Res. 166, 151 (2018), Abstract
A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death: T.L. Thorn, et al.; ASN Neuro. 7, 1177 (2015), Application(s): Cell culture , Abstract — Full Text
A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase: J.B. King, et al.; J. Biol. Chem. 284, 9059 (2009), Abstract
Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase: C. Schmees, et al.; Gastroenterology 132, 1820 (2007), Abstract
Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma: P. Ruoso & D.W. Hedley; Cancer Chemother. Pharmacol. 54, 49 (2004), Abstract
gamma-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liver: E. Obrador, et al.; Hepatology 35, 74 (2002), Abstract
S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase: N. Hogg, et al.; Biochem. J. 323 (Pt2), 477 (1997), Abstract
Metabolism and action of amino acid analog anti-cancer agents: G.S. Ahluwalia et al.; Pharmacol. Ther. 46, 243 (1990), Abstract
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501): L. Allen, et al.; Res. Commun. Chem. Pathol. Pharmacol. 27, 175 (1980), Abstract

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Acivicin

BML-EI113

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