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Ac-YVAD-pNA

ALX-260-026

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Caspase-1 substrate

Sequence is a modification of pro-interleukin-1β Asp-116 cleavage site for caspase-1. Similar to Ac-YVAD-AMC but cleavage is monitored colorimetrically at 405nm.

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Product Details

Alternative Name	Caspase-1 substrate (chromogenic)
Appearance	White to off-white powder.
CAS	149231-66-3
Formula	C₂₉H₃₆N₆O₁₀
Formulation	Lyophilized.
MW	628.6
Peptide Content	75-95%
Purity	≥97% (HPLC)
Sequence	Ac-Tyr-Val-Ala-Asp-pNA (pNA=p-Nitroaniline)
Solubility	Soluble in DMSO. Dilute with buffer pH 7.5.
Technical Info / Product Notes	λmax of pNA is 400nm.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Peptidic p-nitroanilide substrates of interleukin-1 β-converting enzyme: L.A. Reiter; Int. J. Pept. Protein Res. 43, 87 (1994), Abstract
Interleukin-1 β converting enzyme: N.A. Thornberry; Meth. Enzymol. 244, 615 (1994), Abstract
A novel heterodimeric cysteine protease is required for interleukin-1 β processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992), Abstract

Last modified: May 29, 2024

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Ac-YVAD-pNA

ALX-260-026

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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