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Ac-YVAD-CMK

ALX-260-028

14 citations

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Inhibitor of caspase-1 and -4

Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4. Inhibits Fas-mediated apoptosis.

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Product Details

Alternative Name	Caspase-1 inhibitor (chloromethylketone)
Appearance	White to off-white powder.
CAS	178603-78-6
Formula	C₂₄H₃₃N₄O₈Cl
MW	541.0
Purity	≥96% (HPLC)
Sequence	Ac-Tyr-Val-Ala-Asp-chloromethylketone
Solubility	Soluble in DMSO (50mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions should be divided into aliquots and stored at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Osmotic regulation of aquaporin-8 expression in retinal pigment epithelial cells in vitro: Dependence on KATP channel activation: B. Schnabel, et al.; Mol. Vis. 26, 797 (2020), Abstract
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4: Van Opdenbosch, N., Van Gorp, H., et al.; Cell Rep. 21, 3427 (2017), Abstract
A translocator protein 18 kDa ligand, Ro5-4864, inhibits ATP-induced NLRP3 inflammasome activation: J.W. Lee, et al.; Biochem. Biophys. Res. Commun. , (2016), Application(s): Cell culture, Abstract
Enzymatically Inactive Procaspase-1 stabilizes the ASC-Pyroptosome and supports Pyroptosome Spreading during Cell Division: R. Stein, et al.; J. Biol. Chem. 291, 18419 (2016), Application(s): Measuring enzymatic activity of caspase-1, Abstract
An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis: M.V. Nastase, et al.; Am. J. Pathol. 186, 1206 (2016), Abstract
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5: M. Matusiak, et al.; PNAS 112, 1541 (2015), Application(s): Cell Culture, Abstract — Full Text
Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses: G. Mathiak, et al.; Br. J. Pharmacol. 131, 383 (2000), Abstract
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996), Abstract
Involvement of interleukin-1 beta-converting enzyme in apoptosis of bFGF-deprived murine aortic endothelial cells: S. Kondo, et al.; FASEB J. 10, 1192 (1996), Abstract
ICE inhibitor YVADcmk is a potent therapeutic agent against in vivo liver apoptosis: N. Rouquet, et al.; Curr. Biol. 6, 1192 (1996), Abstract

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Ac-YVAD-CMK

ALX-260-028

Product Details

Handling & Storage

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