AMPIVIEW® RNA probes
Enabling Your Projects 
GMP Services
Bulk Solutions
Research Travel Grant
Have You Published Using an Enzo Product?
Inhibitor of caspase-1 and -4
Potent and reversible inhibitor of caspase-1. Also inhibits caspase-4. Strongly inhibits anti-Fas induced apoptosis in L929-Fas cells.
Shipping: Available products typically ship within 24/48h, via priority shipping.
Do you need support? Contact Customer Service or Technical Support.
Online Account
Access or Create Your Account
Product Details
| Alternative Name |
Caspase-1 inhibitor (aldehyde) |
|---|---|
| Appearance |
White powder. |
| Formula |
C23H32N4O8 |
| Formulation |
Lyophilized. |
| MW |
492.5 |
| Peptide Content |
70-90% |
| Purity |
≥96% (HPLC) |
| Reconstitution |
Add 0.2ml DMSO per 1.0mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material. |
| Sequence |
Ac-Tyr-Val-Ala-Asp-CHO |
| Solubility |
Soluble in DMSO or water (both 50mg/ml). |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stock solutions should be divided into aliquots and stored at -20°C. |
|---|---|
| Handling |
Keep under inert gas. Keep cool and dry. |
| Long Term Storage |
-20°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils: I. Demirel, et al.; Sci. Rep. 10, 21837 (2020), Abstract — Full Text
- Proteasome Inhibitor PS-341 Effectively Blocks Infection by the Severe Fever with Thrombocytopenia Syndrome Virus: Liu, S., Liu, H., et al.; Virol Sin. 34, 572 (2019), Abstract
- Gasdermin D plays a vital role in the generation of neutrophil extracellular traps: G. Sollberger, et al.; Sci. Immunol. 3, eaar6689 (2018), Abstract
- Activation of the NLRP3 Inflammasome Pathway by Uropathogenic Escherichia coli Is Virulence Factor-Dependent and Influences Colonization of Bladder Epithelial Cells: Demirel, I., Persson, A., et al.; Front. Cell. Infect. Microbiol. 8, 81 (2018), Abstract
- Omega-3 docosahexaenoic acid induces pyroptosis cell death in triple-negative breast cancer cells: N. Pizato, et al.; Sci. Rep. 8, 1952 (2018), Abstract
- Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells: C. Dai & S.B. Krantz; Blood 93, 3309 (1999), Abstract
- Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract — Full Text
- Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways: Y.Z. Lin, et al.; J. Biol. Chem. 271, 3505 (1996), Abstract — Full Text
- Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996), Abstract
- Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis: M. Los, et al.; Nature 375, 81 (1995), Abstract
- Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro: C.E. Milligan, et al.; Neuron 15, 385 (1995), Abstract
- Interleukin-1 beta converting enzyme: N.A. Thornberry; Methods Enzymol. 244, 615 (1994), Abstract
- Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones: N.A. Thornberry, et al.; Biochemistry 33, 3934 (1994), Abstract
- Structure and mechanism of interleukin-1 β converting enzyme: K.P. Wilson, et al.; Nature 370, 270 (1994), Abstract
- Crystal structure of the cysteine protease interleukin-1 beta- converting enzyme: a (p20/p10)2 homodimer: N.P.C. Walker, et al.; Cell 78, 343 (1994), Abstract
- Interleukin 1 β (IL-1 β) processing in murine macrophages requires a structurally conserved homologue of human IL-1 β converting enzyme: S.M. Molineaux, et al.; PNAS 90, 1809 (1993), Abstract
- Synthesis of a potent, reversible inhibitor of interleukin-1β converting enzyme: K.T. Chapman; Bioorg. Med. Chem. Lett. 2, 613 (1992)
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes: N.A. Thornberry, et al.; Nature 356, 768 (1992), Abstract
Datasheet, Manuals, SDS & CofA
Manuals And Inserts
Certificate of Analysis
Please enter the lot number as featured on the product label
SDS
Enzo Life Science provides GHS Compliant SDS
If your language is not available please fill out the SDS request form