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Ac-YVAD-AFC

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Substrate for caspase-1 and -4

Fluorogenic substrate for caspase-1 and -4.

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Alternative Name	Caspase-1 substrate (fluorogenic), Caspase-4 substrate (fluorogenic)
Appearance	White to off-white powder.
Formula	C₃₃H₃₆F₃N₅O₁₀
MW	719.7
Purity	≥97% (HPLC)
Sequence	Ac-Tyr-Val-Ala-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
Solubility	Soluble in DMSO.
Technical Info / Product Notes	AFC has an excitation maximum of 400nm and an emission maximum of 505nm.

Use/Stability	As indicated on product label or CoA when stored as recommended. Solid product is stable for 1 year in desiccator when stored at room temperature. Stock solutions are stable for 6 – 8 months when stored at –20°C. Keep sealed after removing from the freezer until its temperature equilibrates with room temperature.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

CARD-only proteins regulate in vivo inflammasome responses and ameliorate gout: S. Devi, et al.; Cell Rep. 42, 112265 (2023), Abstract
TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells: M. Furuoka, et al.; J. Cell. Physiol. 231, 2761 (2016), Abstract
Caspase-7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP: M. Marcelli, et al.; Cancer Res. 58, 76 (1998), Abstract

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