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Ac-YVAD-2,6-dimethylbenzoyloxymethylketone

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Inhibitor of caspase-1 and -4

Irreversible, cell permeable inhibitor of caspase-1. Also inhibits caspase-4.

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Alternative Name	Caspase-1 inhibitor, Ac-Tyr-Val-Ala-Asp-2,6-dimethylbenzoyloxymethylketone, Ac-YVAD-AOM
Appearance	White powder.
Formula	C₃₃H₄₂N₄O₁₀
MW	654.7
Peptide Content	78-99%
Purity	≥95% (HPLC)
Sequence	Ac-Tyr-Val-Ala-Asp-2,6-dimethylbenzoyloxymethylketone
Solubility	Soluble in DMSO or methanol.

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions should be divided into aliquots and stored at -20°C.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Ecto-ATPase CD39 Inactivates Isoprenoid-Derived Vγ9Vδ2 T Cell Phosphoantigens: G. Gruenbacher, et al.; Cell Rep. 16, 30728 (2016), Application(s): Bioactivity and cell analysis, Abstract
Inactivation of interleukin-1 beta converting enzyme by peptide (acyloxy)methyl ketones: N.A. Thornberry, et al.; Biochemistry 33, 3934 (1994), Abstract

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