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Ac-WEHD-pNA

ALX-260-082

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Substrate for caspase-1, -4, -5 and -14

Colorimetric caspase substrate. Combinatorial studies have found the WEHD sequence to be optimal for clevage of tetrapeptide substrate by caspase-1, caspase-4, caspase-5 and caspase-14. Cleavage of the substrate by a caspase releases pNA, which can be detected by its absorbance at 405nm.

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Product Details

Alternative Name	Caspase-1 substrate (chromogenic), Caspase-5 substrate (chromogenic)
Appearance	White to yellow powder.
Formula	C₃₄H₃₇N₉O₁₁
Formulation	Lyophilized.
MW	747.7
Peptide Content	70-90%
Purity	≥98% (HPLC)
Sequence	Ac-Trp-Glu-His-Asp-pNA (pNA=p-Nitroaniline)
Solubility	Soluble in DMSO. Dilute with buffer, pH 7.5.
Technical Info / Product Notes	λmax of pNA is 400nm.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Structural transitions enable interleukin-18 maturation and signaling: Dong, Y., Bonin, J. P., et al.; Immunity 57, 1533 (2024), Abstract
Purification and catalytic properties of human caspase family members: M. Garcia-Calvo et al.; Cell Death Differ. 6, 362 (1999), Abstract
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract — Full Text

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Ac-WEHD-pNA

ALX-260-082

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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