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Ac-WEHD-CHO

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Inhibitor of caspase-1, -4, -5 and -14.

Reversible, cell permeable inhibitor of caspase-1 and -5. Also inhibits caspase-4 and -14.

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Alternative Name	Caspase-1 inhibitor (aldehyde), Caspase-5 inhibitor (aldehyde)
Appearance	White to off-white powder.
Formula	C₂₈H₃₃N₇O₉
Formulation	TFA salt.
MW	611.6
Purity	≥90% (HPLC)
Sequence	Ac-Trp-Glu-His-Asp-CHO
Solubility	Soluble in water (10mg/ml).

Use/Stability	As indicated on product label or CoA when stored as recommended. Solution is stable for 1 month when stored at -20°C and protected from light.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps: G. Sollberger, et al.; Sci. Immunol. 3, eaar6689 (2018), Abstract
Design and application of a fluorogenic assay for monitoring inflammatory caspase activity: R. Ranganathan, et al.; Anal. Biochem. 543, 1 (2017), Abstract
A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE): T.A. Rano, et al.; Chem. Biol. 4, 149 (1997), Abstract
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis: N.A. Thornberry, et al.; J. Biol. Chem. 272, 17907 (1997), Abstract — Full Text

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