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Ac-WEHD-AFC

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Substrate for caspase-1, -4-, -5 and -14

Fluorogenic substrate for caspase-1, -4, -5 and -14.

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Alternative Name	Caspase-1 substrate (fluorogenic), Caspase-5 substrate (fluorogenic)
Appearance	White to yellow powder.
Formula	C₃₈H₃₇F₃N₈O₁₁
MW	838.8
Peptide Content	70-90%
Purity	≥98% (HPLC)
Sequence	Ac-Trp-Glu-His-Asp-AFC (AFC=7-Amino-4-trifluoromethylcoumarin)
Solubility	Soluble in DMSO.
Technical Info / Product Notes	AFC has an excitation maximum of 400nm and an emission maximum of 505nm.

Use/Stability	As indicated on product label or CoA when stored as recommended. Solution in DMSO is stable for 6-8 months when stored at -20°C.
Handling	Keep cool and dry.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold: B.B. Verdugo, et al.; J. Biol. Chem. 298, 101931 (2022), Abstract
Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome: R.V.H. De Carvalho, et al.; Cell Rep. 26, 429 (2019), Abstract
Noninvasive evaluation of the chronic influence of local air velocity from an air conditioner using salivary cortisol and skin caspase-14 as biomarkers of psychosomatic and environmental stress: M. Yamaguchi, et al.; J. Int. Med. Res. 40, 1429 (2012), Abstract

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